Heart Health: Pycnogenol® + Coenzyme Q10

By: Crystal Shelton

There is certainly no shortage of research documenting the far-reaching effects of the exclusive pine bark extract known as Pycnogenol®, including its applications for heart health. With regards to coenzyme Q10, one can also find limitless studies to support its role in cardiovascular function and health.

The Study:

Recently, an investigation was conducted to determine the effects of the combination of Pycnogenol® and coenzyme Q10 in heart failure patients. In order to evaluate the combined efficacy of Pycnogenol® and coenzyme Q10, 53 patients who had been diagnosed with heart failure were enrolled in the study. Patients were divided into two groups, one group receiving capsules containing 350 mg of coenzyme Q10 and 105 mg of Pycnogenol® and the second group receiving comparable placebo capsules in addition to their individual medications for a 12 week period.

The Results:

Measurements such as ventricular function, walking distance, and leg fluid were all part of the assessments and observations for this study. All included patients were defined as having mild to moderate hypertension. There was a significant decrease (-8%) of systolic and diastolic pressure, as well as a decrease in heart rate in the group treated with Pycnogenol and coenzyme Q10. Additionally, this group also had a decrease in the respiratory rate that was more significant that that in the control group. After 12 weeks, patients treated with Pycnogenol and coenzyme Q10 were said to have improved their quality of life as validated by the Karnofsky index, this improvement was not noted in the control group.

What it means:

This observational study emphasizes the positive effects of Pycnogenol and coenzyme Q10 on cardiovascular health, while also noting the combination of the two ingredients can have significant impacts on heart failure patients. This study documented no side effects and very good tolerability. The researchers conclude, “The association of Pycnogenol and CoQ10 may offer an important therapeutic option in the management and costs of heart failure.”



Belcaro G1, Cesarone MR, Dugall M, Hosoi M, Ippolito E, Bavera P, Grossi MG. Investigation of Pycnogenol® in combination with coenzymeQ10 in heart failure patients (NYHA II/III). Panminerva Med. 52(2 Suppl 1):21-5, 2010.