High Dose Vitamin D Reduces Arterial Stiffness

By: Mark Lange, PhD

Vitamin D deficiency may be a contributor to rigid artery walls – a predictor of cardiovascular disease.  A four-month study of 70 African-Americans ages 13-45 – all with some degree of arterial stiffness – took 4000 IU of vitamin D3 daily.  Arterial stiffness improved with vitamin D supplementation in a dose-response manner within this population.  Participants saw a 10.4 percent reduction in arterial stiffness.  Participants taking 2000 IU vitamin D3 daily had a 2 percent reduction.

Heart disease is the leading cause of death in the United States.  African-Americans have higher rates than other populations and the disease tends to occur earlier in life.  The authors write that arterial stiffness and vitamin D deficiency might be potential contributors.

More than 80% of American have vitamin D insufficiency or deficiency.


Source:  Anas Raed, et al.  Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.  PLOS ONE 2017; 12 (12)